Worldwide allele frequencies of the human apolipoprotein E gene: Climate, local adaptations, and evolutionary history

Dan Eisenberg, third-year PhD student at Northwestern University, and colleagues have a new paper in Early View in AJPA. They explore worldwide distribution of the apolipoprotein E 3 alelle (which is implicated in cardiovascular disease and elevated cholesterol), and its association with climate data to evaluate the hypothesis that population variation in ApoE3 is due to metabolic constraints of varying environments.

Worldwide allele frequencies of the human apolipoprotein E gene: Climate, local adaptations, and evolutionary history